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Transdermal absorption technology for controlled release of Western Medicine


Technical Indicators for Transdermal Absorption of SAB

Applicable Drugs: Natural Extracted Drugs or Organic Peptides (Molecular Weight less than 2000)

Effective Transdermal Absorption: The Transdermal Dose can reach 2mg/Square cm

Safety: No irritation to skin or allergies

Carbaratin transdermal patch for Alzheimer's disease 

The advantages of using transdermal patches to change the route of administration:

1. Skin absorption and systemic circulation

2. Fixed-rate transmission keeps blood concentration constant

3. Sustained-release and long-acting (up to 7 days per patch)

4. Specific constitution (allergy) facilitates discontinuation of medicines

5. Reducing digestive system irritation or affecting drug absorption

6. Novel, convenient and effective

7. Reducing the First-pass Effect of Liver and Lowering the Liver Load

Omeprazole transdermal patch: treatment of gastric ulcer and gastroesophageal reflux


Development background of gastrointestinal ulcer and gastroesophageal reflux patch

The most effective drug for gastrointestinal ulcer and gastroesophageal reflux is omeprazole, a proton pump inhibitor, which is usually taken once a day. The common problems are insufficient efficacy (such as taking medicine in the morning, causing gastrointestinal pain due to insufficient blood concentration in the late night) or the rapid and slow metabolism of drugs due to personal genetic constitution, resulting in instability of efficacy. Ding (first-pass effect of liver).

It is difficult for bedridden patients to administer drugs in the gastrointestinal tract or because the gastrointestinal tract can not absorb drugs due to pathological changes, resulting in poor curative effect.

Advantages of Omeprazole Patch

1. Effective and stable route of administration.

2. Oral Omeprazole Capsule has its shortcomings and limitations, especially the pain caused by acid reflux in the middle of the night due to half-life problems. If the patch is absorbed through the skin, and the efficacy of the patch can be maintained for 7 days, it has the advantages of necessity and convenience in clinical practice.

3. A three-day or seven-day patch is the best preparation for gastrointestinal diseases.

4. Easy to use by patients

5. Do not interfere with gastrointestinal symptoms and drug absorption.

6. The group of patients is very large.


Bottlenecks in the development of transdermal Absorbents


Skin cuticle is an important protective mechanism for human body. Without destroying the structure of cuticle, most drugs can hardly pass through the skin. Even some drugs can pass through the skin, but the dose of penetration is far less than the dose required for treatment. Therefore, despite decades of research and development, only 16 transdermal drugs have been successfully absorbed so far.

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